Description
PGI
3 is synthesized from EPA by COX and PGI synthase. PGI
3 has a short
in vivo half-
life and is hydrolyzed to Δ
17-
6-
keto PGF
1α. The platelet and vascular activity of PGI
3 is equivalent to that of PGI
2.
1,2
References
1. Mann, N.J., Warrick, G.E., O'Dea, K., et al.
The effect of linoleic, arachidonic, and eicosapentaenoic acid supplementation of prostacyclin production in rats Lipids 29(3),157-162(1994).
2. Johnson, R.A., Lincoln, F.H., Nidy, E.G., et al.
Synthesis and characterization of prostacyclin, 6-ketoprostaglandin F1α, prostaglandin I1, and prostaglandin I3 J. Am. Chem. Soc. 100(24),7690-7704(1978).
