68324-96-9

PGI₃ is synthesized from EPA by COX and PGI synthase. PGI₃ has a short in vivo half-life and is hydrolyzed to Δ¹⁷-6-keto PGF_1α. The platelet and vascular activity of PGI₃ is equivalent to that of PGI₂.^1,2

1. Mann, N.J., Warrick, G.E., O'Dea, K., et al. The effect of linoleic, arachidonic, and eicosapentaenoic acid supplementation of prostacyclin production in rats Lipids 29(3),157-162(1994).
2. Johnson, R.A., Lincoln, F.H., Nidy, E.G., et al. Synthesis and characterization of prostacyclin, 6-ketoprostaglandin F_1α, prostaglandin I₁, and prostaglandin I₃ J. Am. Chem. Soc. 100(24),7690-7704(1978).