81703-55-1

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI₂. Ciprostene exhibits biological activity similar to PGI₂, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID₅₀ values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Platelet aggregation inhibitor.

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