Originator
Abovis ,Toyama ,Japan ,1981
Uses
Aclatonium Napadisilate is a useful bioactive therapeutic agent for autoimmune diseases. A cholinergic agonist.
Manufacturing Process
5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of
acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto.
This mixture was refluxed for 3 hours. The resulting reaction mixture was
allowed to stand at room temperature while cooling to precipitate the desired
product crystals, which were collected by filtration. 5.5 g (76% yield) of the
desired product having a melting point of 189°C to 191°C were obtained.
Therapeutic Function
Cholinergic
Safety Profile
Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent.
