Notoginseng triterpenes

Chemical Properties

Notoginsenoside Fe is a natural compound isolated from Panax japlcus var.Notoginsenoside Fe is a naturally occurring compound in Panax notoginseng, a herb used in the treatment of cardiovascular diseases in traditional Chinese medicine.
Notoginsenoside Fe belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. Notoginsenoside Fe is an extremely weak basic (essentially neutral) compound (based on its pKa).

Description

Notoginseng triterpenes (NTs) are the active components extracted from Panax notoginseng, reducing oxygen consumption and improving the body’s tolerance to hypoxia. However, their role in random flap survival has not been elucidated. In this study, we used a mouse random skin flap model to verify that NT can promote cell proliferation and migration and that increasing blood perfusion can effectively improve the survival area of a skin flap.

Uses

Notoginsenoside Fe is medicinal herb from Panax ginseng which exert immunomodulatory and anti-inflammatory activities.

Definition

ChEBI: Notoginsenoside Fe is a triterpenoid.

Biological Activity

Notoginsenoside Fe is a saponin and metabolite of ginsenoside Rc (Item No. 29088) that has been found in P. notoginseng. It is cytotoxic to L1210 murine skin lymphocytic leukemia cells (IC50 = 80 μM).

target

IL Receptor | PKC