ISOBAVACHALCONE

Uses

Isobavachalcone is an inhibitor of platelet aggregation.

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.

Biological Activity

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia th at inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears th at isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.