Synthesis
Example 171A Synthesis of 3-(ethoxycarbonyl)piperidine hydrochloride: thionyl chloride (22.5 mL) was slowly added dropwise to a solution of ethanol (40 mL) containing piperidine-3-carboxylic acid (10.7 g, 83 mmol) at 0 °C. Subsequently, the reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure to afford the target product 3-(ethoxycarbonyl)piperidine hydrochloride (13 g, yield: 100%). The product was analyzed by LC-MS (ESI) and showed m/z: 158 ([M+H]+).
References
[1] Patent: US2009/197863, 2009, A1. Location in patent: Page/Page column 80
[2] Patent: WO2018/26779, 2018, A1. Location in patent: Page/Page column 30; 31
[3] Patent: US2009/62268, 2009, A1. Location in patent: Page/Page column 47-48
