1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- Product Name1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- CAS124011-52-5
- CBNumberCB7380181
- MFC42H84NaO10P
- MW803.09
- MDL NumberMFCD03454063
- MOL File124011-52-5.mol
Chemical Properties
solubility | Chloroform:2.0(Max Conc. mg/mL);2.5(Max Conc. mM) |
form | A crystalline solid |
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Cayman Chemical 15087 | 100 mg | $82 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% |
Buy |
Cayman Chemical 15087 | 250 mg | $194 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% |
Buy |
Cayman Chemical 15087 | 500 mg | $368 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% |
Buy |
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Chemical Properties,Usage,Production
Description
DSPG is used in FDA approved drugs. It is an anionic phospholipid derivative. DSPG has been used to form an ionic complex with amphotericin B and encapsulate it into small unilamellar liposomes with significantly reduced toxicity (AmBisome?). DSPG-Na is a lipid reagent, which is useful in drug formulation, DNA & RNA delivery.in vitro
Three liposome formulations were investigated: HSPC:Chol (L-EPI; 5:4 molar ratio), HSPC:Chol:DSPG (D-EPI; 5:4:1 molar ratio), and HSPC:Chol:DSPG:DSPE-mPEG(2000) (S-EPI; 5:4:1:0.3 molar ratio). Small unilamellar liposomes were prepared by the modified thin-film hydration method with extrusion through polycarbonate filters, and EPI was remote loaded into liposomes by the transmembrane ammonium sulfate gradient method._x000D_ _x000D_ Reference: J Liposome Res. 2012 Mar;22(1):80-8. https://pubmed.ncbi.nlm.nih.gov/22022836/in vivo
Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis._x000D_ _x000D_ Reference: J Control Release. 2018 Dec 10;291:135-146. https://pubmed.ncbi.nlm.nih.gov/30365993/target
A phospholipid.Preparation Products And Raw materials
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Suppliers
Global(29)Suppliers
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info@shochem.com | China | 309 | 58 | |
+86-0731-85567275 13021512891 |
sales02@chemfish.com | China | 6583 | 58 |
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