Chemical Properties
Tan Solid
Uses
A mitotic kinesin inhibitor as novel anti-cancer agent. Used in the study of neurodegenerative diseases.
Uses
A mitotic kinesin inhibitor as novel anti-cancer agent.
Uses
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole is used in the study of neurodegenerative diseases
Definition
ChEBI: 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole is a member of beta-carbolines.
General Description
Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9
H-pyrido[3,4-
b]indole derivatives was studied.
in vivo
Tetrahydro-β-carboline (20 μg; i.c.v.) increases the serotonin levels in the same part of the brain in rats[1].
Animal Model: | 180-200g female Sprague-Dawley rats[1] |
Dosage: | 20 μg |
Administration: | Intraventricular injection |
Result: | Increased of serotonin levels in the same part of the brain whereas the monoamine oxidase activity was not altered. |
IC 50
serotonin: 6.1 μM (Ki)