Description
The prostaglandin E
2 (PGE
2) receptor (EP
1) is involved in triggering PGE
2-
mediated pain as well as neuronal survival and growth. SC-
51322 is a selective EP
1 antagonist that inhibits PGE
2 signaling in a guinea pig ileum muscle strip assay with a pA
2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED
50 value of 0.9 mg/kg. It is pharmacologically similar to SC-
51089, but does not release hydrazine, a known carcinogen to rats, as does SC-
51089. SC-
51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE
2 with an EC
50 value of 7.75 μM.
