146032-79-3

The prostaglandin E₂ (PGE₂) receptor (EP₁) is involved in triggering PGE₂-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP₁ antagonist that inhibits PGE₂ signaling in a guinea pig ileum muscle strip assay with a pA₂ value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED₅₀ value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE₂ with an EC₅₀ value of 7.75 μM.

Off-White Solid

A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.

EP2: 8.1 (pA2)

Store at -20°C

[1] E. ANN HALLINAN. Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs[J]. Journal of Medicinal Chemistry, 1996, 39 2: 609-613. DOI: 10.1021/jm950454k
[2] N FOUDI. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype[J]. British Journal of Pharmacology, 2009, 154 8: 1631-1639. DOI: 10.1038/bjp.2008.214