19313-28-1

13,14-dihydro Prostaglandin E₁ (13,14-dihydro PGE₁) is a biologically active metabolite of PGE₁ with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 31 and 21 nM, respectively. 13,14-dihydro PGE₁ is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE₁ which has an IC₅₀ value of 40 nM. Also, 13,14-dihydro PGE₁ was shown to activate adenylate cyclase in NCB-20 hybrid cells with a K_act value of 668 nM.

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.

ChEBI: 13,14-Dihydro PGE1 is a prostanoid.

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