Description
Prostaglandin D
2 (PGD
2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD
2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD
2 is also produced in the brain
via an alternative pathway involving a soluble, secreted PGD-
synthase also known as β-
trace. In the brain, PGD
2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD
2 inhibits human ovarian tumor cell proliferation with an IC
50 of 6.8 μM.
Definition
ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s
ereoisomer).
References
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10.4049/jimmunol.1900745[7] AKIKO SUGANAMI. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands[J]. The FEBS journal, 2016, 283 21: 3931-3940. DOI:
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