Description
13,14-
dihydro Prostaglandin E
1 (13,14-
dihydro PGE
1) is a biologically active metabolite of PGE
1 with comparable potency to the parent compound. It is an inhibitor of ADP-
induced platelet aggregation in human PRP and washed platelets with IC
50 values of 31 and 21 nM, respectively. 13,14-
dihydro PGE
1 is a slightly more potent inhibitor of ADP-
induced human platelet aggregation than PGE
1 which has an IC
50 value of 40 nM. Also, 13,14-
dihydro PGE
1 was shown to activate adenylate cyclase in NCB-
20 hybrid cells with a K
act value of 668 nM.
Uses
Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.
