Description
13,14-
dihydro Prostaglandin E
1 (13,14-
dihydro PGE
1) is a biologically active metabolite of PGE
1 with comparable potency to the parent compound. It is an inhibitor of ADP-
induced platelet aggregation in human PRP and washed platelets with IC
50 values of 31 and 21 nM, respectively. 13,14-
dihydro PGE
1 is a slightly more potent inhibitor of ADP-
induced human platelet aggregation than PGE
1 which has an IC
50 value of 40 nM. Also, 13,14-
dihydro PGE
1 was shown to activate adenylate cyclase in NCB-
20 hybrid cells with a K
act value of 668 nM.
Uses
Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.
Definition
ChEBI: 13,14-Dihydro PGE1 is a prostanoid.
References
[1] [1] NGGRD E. The Biological Activities of Three Metabolites of Prostaglandin E1[J]. Acta Physiologica, 1966, 66 4: 509-510. DOI:
10.1111/j.1748-1716.1966.tb03231.x[2] M. HAMBERG B S. On the Metabolism of Prostaglandins E1 and E2 in Man[J]. Journal of Biological Chemistry, 1971, 246 1: 6713-6721. DOI:
10.1016/s0021-9258(19)45905-x[3] G. KOBZAR. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets[J]. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1993, 106 2: Pages 489-494. DOI:
10.1016/0742-8413(93)90168-k[4] I. JRVING. ANTIAGGREGATING POTENCY OF E-TYPE PROSTAGLANDINS IN HUMAN AND RABBIT PLATELETS[J]. Proceedings of the Estonian Academy of Sciences. Chemistry, 1991, 32 1. DOI:
10.3176/chem.1991.3.09[5] I.A. BLAIR J. M C N HENSBY. PROSTACYCLIN-DEPENDENT ACTIVATION OF ADENYLATE CYCLASE IN A NEURONAL SOMATIC CELL HYBRID: PROSTANOID STRUCTURE-ACTIVITY RELATIONSHIPS[J]. British Journal of Pharmacology, 1980, 69 3: 519-525. DOI:
10.1111/j.1476-5381.1980.tb07043.x
