Description
Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium
channel blocker verapamil with a similar profile. It is useful in the treatment of
angina and auricular arrhythmia.
Originator
Knoll (W. Germany)
Uses
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].
brand name
Benpredil;Corapamil;PROCORUM.
in vivo
Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].
| Animal Model: | Male Wistar rats weighing 290-370 g[3] |
| Dosage: | 0.2 mg/kg |
| Administration: | i.v.; 5 min |
| Result: | Markedly reduced VT and totally prevented VF.
|
References
[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:
10.2165/00003495-199447010-00007[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:
10.1159/000137824[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:
10.1111/j.1440-1681.1991.tb01434.x
