METHOXYVERAPAMIL HYDROCHLORIDE

Product NameMETHOXYVERAPAMIL HYDROCHLORIDE
CAS16662-46-7
MFC28H41ClN2O5
MW521.09
EINECS2407047
MOL File16662-46-7.mol

Chemical Properties

Melting point	145-148°
storage temp.	Store at -20°C
solubility	DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form	A crystalline solid
color	White to off-white

Safety Information

WGK Germany

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Description

Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium channel blocker verapamil with a similar profile. It is useful in the treatment of angina and auricular arrhythmia.

Originator

Knoll (W. Germany)

Uses

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

brand name

Benpredil;Corapamil;PROCORUM.

in vivo

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate^[3].

Animal Model:	Male Wistar rats weighing 290-370 g^[3]
Dosage:	0.2 mg/kg
Administration:	i.v.; 5 min
Result:	Markedly reduced VT and totally prevented VF.

References

[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x

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