Description
Tobramycin Sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis.
Originator
Nebcin (Lilly).
Uses
Tobramycin Sulfate is an antibiofilm formulations.
Indications
Used in the treatment of septicemia (bloodstream infection), infections of the skin, bone, lower respiratory tract, central nervous system, intra-abdominal and complicated recurrent urinary tract infections.
Side effects
The most common side effects of Tobramycin sulfate include:
- Nephrotoxicity (Kidney Toxicity)
Tobramycin sulfate, like other aminoglycosides, can cause nephrotoxicity. This toxicity is usually reversible discontin uponuation of the drug. It is more likely to occur with prolonged use or in patients with pre-existing kidney dysfunction.
- Ototoxicity (Ear Toxicity)
Ototoxicity is another common side effect, which can manifest as vestibular dysfunction or hearing loss. This toxicity is often irreversible and may be more prevalent in patients with genetic predispositions.
