1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHO-L-SERINE SODIUM SALT

Description

DLPS, also known as 1,2-dilauroyl-sn-glycero-3-phospho-L-serine, is an anionic phospholipid with lauric acid tails (12:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls.

Uses

12:0 PS may be used:

• in the preparation of large unilamellar vesicles (LUVs)
• as a standard to spike replicas of extracted lipid droplets?and calibration curve generation for lipidomic analysis
• to study its effects on α-secretase activity

General Description

Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets.

Biochem/physiol Actions

Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol.