Description
Scutellarein is a flavone that has been isolated from
S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC
50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.
In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.
References
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10.1055/s-0029-1243121[2] JACKELINE TIEMY GUINOZA SIRAICHI. Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil.[J]. PLoS ONE, 2013: e72733. DOI:
10.1371/journal.pone.0072733[3] JUN KAWABATA. 6-hydroxyflavonoids as alpha-glucosidase inhibitors from marjoram (Origanum majorana) leaves.[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67 2: 445-447. DOI:
10.1271/bbb.67.445[4] MI-SUN YU . Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 12: Pages 4049-4054. DOI:
10.1016/j.bmcl.2012.04.081[5] NAK YOON SUNG Jae Y C Mi Yeon Kim. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity.[J]. Korean Journal of Physiology & Pharmacology, 2015, 19 5: 441-449. DOI:
10.4196/kjpp.2015.19.5.441[6] XIUJUAN SHI. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.[J]. International journal of molecular medicine, 2015, 35 1: 31-38. DOI:
10.3892/ijmm.2014.1997
