Tolmetin sodium

Tolmetin sodium Structure
Tolmetin sodium
  • CAS No.35711-34-3
  • Chemical Name:Tolmetin sodium
  • CBNumber:CB6397353
  • Molecular Formula:C15H14NNaO3
  • Formula Weight:279.27
  • MOL File:35711-34-3.mol
Tolmetin sodium Property
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
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Tolmetin sodium Price More Price(7)
  • Brand: Sigma-Aldrich
  • Product number: 1670502
  • Product name : Tolmetin sodium
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 500 mg
  • Price: $366
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: T535375
  • Product name : Tolmetin sodium
  • Purity: 
  • Packaging: 25mg
  • Price: $165
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: American Custom Chemicals Corporation
  • Product number: API0016245
  • Product name : TOLMETIN SODIUM
  • Purity: 95.00%
  • Packaging: 1G
  • Price: $1158.15
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: American Custom Chemicals Corporation
  • Product number: API0016245
  • Product name : TOLMETIN SODIUM
  • Purity: 95.00%
  • Packaging: 5MG
  • Price: $502.11
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alichem
  • Product number: 35711343
  • Product name : Sodium2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate
  • Purity: 
  • Packaging: 1g
  • Price: $515
  • Updated: 2021/12/16
  • Buy: Buy

Tolmetin sodium Chemical Properties,Usage,Production

  • Originator Tolectin,McNeil,US,1976
  • Uses Tolectin (Ortho-McNeil).
  • Uses Tolmetin Sodium is a non-steroidal anti-inflammatory drug.
  • Manufacturing Process 5-(p-Toluoyl)-1-methylpyrrole-2-acetonitrile - To a cooled suspension of 26.6 g (0.2 mol) aluminum chloride in 80 ml dichloroethane is added dropwise 30.8 g (0.2 mol) p-toluoyl chloride. The resulting solution is added dropwise to a solution of 1-methylpyrrole-2-acetonitrile in 80 ml dichloroethane cooled externally with an ice bath. After the addition, the resulting solution is stirred at room temperature for 20 minutes and then refluxed for 3 minutes. The solution is poured into ice acidified with dilute hydrochloric acid. The organic and aqueous fractions are separated. The aqueous fraction is extracted once with chloroform.
    The organic fractions are combined and washed successively with N,N_x0002_dimethyl-1,3-propanediamine, dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic fraction is dried over anhydrous magnesium sulfate. The solvent is then evaporated off. Upon trituration of the residue with methanol, a solid crystallizes, 5-(p-toluoyl)-1-methylpyrrole-2-acetonitrile, which is removed by filtration and purified by recrystallization from benzene.
    Additional product is isolated from the mother liquors which are combined, concentrated in vacuo and the resulting oily residue column chromatographed on neutral alumina using hexane, benzene and ether as successive solvents. The product is isolated by concentrating in vacuo the first few major compound-bearing fractions (10% ether in benzene). The solids are combined and recrystallized from methanol and then from benzene-hexane, melting point 102°C to 105°C.
    5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid - A solution of 3.67 g (0.015 mol) of 5-(p-toluoyl)-1-methylpyrrole-2-acetonitrile, 24 ml of 1 N sodium hydroxide and 50 ml of 95% ethanol is stirred and refluxed for 24 hours. The resulting solution is poured into ice acidified with dilute hydrochloric acid. A white solid precipitates which is extracted into ether. The ether phase is washed with a saturated solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent is evaporated and a white solid, 5-(p-toluoyl)- 1-methylpyrrole-2-acetic acid is obtained which is recrystallized twice from isopropanol, melting point 155°C to 157°C.
  • Therapeutic Function Antiinflammatory
  • Pharmacokinetics Tolmetin sodium is rapidly and almost completely absorbed on oral administration, with peak plasma levels being attained within the first hour of administration. It has a relatively short plasma half-life of approximately 1 hour because of extensive first-pass metabolism, involving hydroxylation of the p-methyl group to the primary alcohol, which is subsequently oxidized to the dicarboxylic acid.
  • Clinical Use Tolmetin is synthesized straightforwardly from 1-methylpyrrole. It was introduced in the United States in 1976 and like other NSAIDs, inhibits prostaglandin biosynthesis. Tolmetin, however, also inhibits polymorph migration and decreases capillary permeability. Its anti-inflammatory activity, as measured in the carrageenan-induced rat paw edema and cotton pellet granuloma assays, is intermediate between those of phenylbutazone and indomethacin.
  • Side effects The most frequently adverse reactions are those involving the GI tract (e.g., abdominal pain, discomfort, and nausea) but appear to be less than those observed with aspirin. The CNS effects (e.g., dizziness and drowsiness) also are observed. Few cases of overdosage have been reported, but in such cases, recommended treatment includes elimination of the drug from the GI tract by emesis or gastric lavage and elimination of the acidic drug from the circulatory system by enhancing alkalinization of the urine with sodium bicarbonate.
  • Metabolism This metabolite is inactive in standard in vivo anti-inflammatory assays. The free acid (pKa = 3.5) is highly bound to plasma proteins (99%), and excretion of tolmetin and its metabolites occurs primarily in the urine.Approximately 15 to 20% of an administered dose is excreted unchanged and 10% as the glucuronide conjugate of the parent drug. Conjugates of the dicarboxylic acid metabolite account for the majority of the remaining administered drug.
Tolmetin sodium Preparation Products And Raw materials
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Tolmetin sodium Suppliers
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