Description
7-
Nitroindazole is a non-
selective inhibitor of NOS isoforms
in vitro. However, it shows good anti-
nociceptive effects
in vivo without affecting blood pressure
via inhibition of eNOS. The IC
50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively.
Chemical Properties
yellow powder or Yellow orange solid soluble in DMSO.
Uses
7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.
Definition
7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).
Biological Activity
Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole).
