Basic information Safety Related Supplier

ChemicalBook Product Catalog 7-Nitroindazole

1/1

7-Nitroindazole NEW

$ 29.00 /200mg

Min. Order
Purity96.15%
Cas No2942-42-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	7-Nitroindazole
CAS No	2942-42-9
EC-No
Min. Order
Purity	96.15%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	7-Nitroindazole
Description	7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
Animal Research	Animals were divided into four groups (n = 12) as follows:group 1: control animals, treated with saline for 7 days, which were involved in the experiment from the very beginning and housed under the same standard laboratory conditions as the treated animals;group 2: animals, receiving 15 mg/kg?1 i.p. of cocaine for 7 days;group 3: animals, receiving 25 mg/kg?1 i.p. 7-NI for 7 days ;group 4: animals, treated with 7-NI (25 mg/kg?1 i.p.) and 30 min later with cocaine (15 mg/kg?1) for 7 days.Twenty-four hours after the last administration of the compounds the animals were observed for behavioral changes related to the withdrawal syndrome.?Then the animals were sacrificed through decapitation and brains were extracted.?Brains of six animals from each group were taken for isolation of synaptosomes and brains from the other six animals of each group were used for measurement of nNOS and antioxidant enzymes[1].
In vivo	In the experimental model of cocaine multiple administration in rats the selective nNOS inhibitor 7-nitroindazole not only attenuated the behavioral changes induced by cocaine deprivation but also exerted an antioxidant and neuroprotective activity.?The possible mechanisms underlying the neuroprotective effects of 7-NI could be due to the combination of its inhibitory effect of nNOS and its direct free radical scavenging properties.?The beneficial effect of 7-NI in restoration of the antioxidant cell defense in the brain, impaired by multiple cocaine administration, and along with it the attenuation of the physical dependence, induced by cocaine, once again confirm the role of the oxidative stress in the development of addiction to psychoactive compounds[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 32 mg/mL (196.16 mM)
Keywords	Inhibitor \| inhibit \| 7Nitroindazole \| 7 Nitroindazole \| Nitric oxide synthases \| 7-Nitroindazole \| NO Synthase \| NOS
Inhibitors Related	L-NAME hydrochloride \| Dexamethasone acetate \| Diallyl disulfide
Related Compound Libraries	Nonsteroidal Anti-Inflammatory Compound Library \| Bioactive Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Human Metabolite Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book