ChemicalBook CAS DataBase List MFCD00167693

MFCD00167693

Product NameMFCD00167693
CAS199735-88-1
CBNumberCB63058321
MFC15H13Cl2NO3
MW326.17
MDL NumberMFCD00167693
MOL File199735-88-1.mol
MSDS FileSDS

Chemical Properties

Boiling point	569.1±50.0 °C(Predicted)
Density	1.529±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:157.5(Max Conc. mg/mL);482.87(Max Conc. mM) Ethanol:65.0(Max Conc. mg/mL);199.28(Max Conc. mM)
form	A solid
pka	4.19±0.40(Predicted)
color	White to off-white
InChI	1S/C15H13Cl2NO3/c16-10-4-3-9(6-11(10)17)18-14(19)12-7-1-2-8(5-7)13(12)15(20)21/h1-4,6-8,12-13H,5H2,(H,18,19)(H,20,21)
InChIKey	YSDNWNOGHQYWPK-UHFFFAOYSA-N
SMILES	O=C(C1C2C=CC(C1C(NC3=CC=C(C(Cl)=C3)Cl)=O)C2)O
UNSPSC Code	12352200
NACRES	NA.21

Safety

Symbol(GHS)
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

MFCD00167693 Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich S720224	50MG	$121	3-(N-(3,4-DICHLOROPHENYL)CARBAMOYL)-5-NORBORNENE-2-CARBOXYLIC ACID AldrichCPR	Buy
Cayman Chemical 36679	5mg	$49	CADD522 ≥98%	Buy
Cayman Chemical 36679	25mg	$171	CADD522 ≥98%	Buy
Cayman Chemical 36679	100mg	$482	CADD522 ≥98%	Buy
Cayman Chemical 36679	250mg	$723	CADD522 ≥98%	Buy

MFCD00167693 Chemical Properties,Usage,Production

Uses

CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA.

Biological Activity

CADD522 is a cell-permeable, bioavailable, non-toxic carbamoyl-bicycloheptene-carboxylate th at inhibits RUNX2-DNA binding, thereby increases RUNX2 stability, upregulates RUNX2 expression levels and downregulates RUNX2 responsive genes transcription. CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate and ATP production in human breast cancer cells in a RUNX2-independent manner. CADD-522 suppresses in vivo tumor growth and metastasis, and appreciably prolongs the survival rates without the need for surgery or chemotherapy.

in vivo

CADD522 (1, 5 and 20 mg/kg; i.p.; twice a week for 45 days) delays the onset of the tumors and suppresses tumor growth in mice^[1].
CADD522 (10 mg/kg; i.p.; twice a week for 11 days) suppresses tumor metastasis and inhibits expression of Ki-67 in mice^[1].

Animal Model:	Female mice (6-week-old; MMTV-PyMT transgenic model)^[1].
Dosage:	1, 5 and 20 mg/kg
Administration:	Intraperitoneal injection; twice a week for 45 days.
Result:	Delayed the onset of the tumors, delayed tumor development and reduced tumor burden in transgenic MMTV-PyMT mice. Reduced the tumor weight in mice.

Animal Model:	Female NOD scid gamma (NSG) mice and nude mice (TNBC-PDX Br-001 model)^[1].
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; twice a week for 11 days.
Result:	Significant decreased tumor volume and markedly inhibited expression of Ki-67. Inhibited experimental metastasis of BC cells in vivo.(did not significantly decrease body weight or influence the general health of animals).

IC 50

RUNX2: 10 nM ()

Preparation Products And Raw materials

MFCD00167693 Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	18916372613	yanzihan@shyuanye.com	China	87240	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9767	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2961	58
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28149	68
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	sales@linyuepharm.com	China	5760	55
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2934	58

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