ChemicalBook CAS DataBase List 199735-88-1

199735-88-1

Name	MFCD00167693
CAS	199735-88-1
Molecular Formula	C15H13Cl2NO3
MDL Number	MFCD00167693
Molecular Weight	326.17
MOL File	199735-88-1.mol

Chemical Properties

Boiling point	569.1±50.0 °C(Predicted)
density	1.529±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO:157.5(Max Conc. mg/mL);482.87(Max Conc. mM) Ethanol:65.0(Max Conc. mg/mL);199.28(Max Conc. mM)
form	A solid
pka	4.19±0.40(Predicted)
color	White to off-white
InChI	1S/C15H13Cl2NO3/c16-10-4-3-9(6-11(10)17)18-14(19)12-7-1-2-8(5-7)13(12)15(20)21/h1-4,6-8,12-13H,5H2,(H,18,19)(H,20,21)
InChIKey	YSDNWNOGHQYWPK-UHFFFAOYSA-N
SMILES	O=C(C1C2C=CC(C1C(NC3=CC=C(C(Cl)=C3)Cl)=O)C2)O

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA.

Biological Activity

CADD522 is a cell-permeable, bioavailable, non-toxic carbamoyl-bicycloheptene-carboxylate th at inhibits RUNX2-DNA binding, thereby increases RUNX2 stability, upregulates RUNX2 expression levels and downregulates RUNX2 responsive genes transcription. CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate and ATP production in human breast cancer cells in a RUNX2-independent manner. CADD-522 suppresses in vivo tumor growth and metastasis, and appreciably prolongs the survival rates without the need for surgery or chemotherapy.

in vivo

CADD522 (1, 5 and 20 mg/kg; i.p.; twice a week for 45 days) delays the onset of the tumors and suppresses tumor growth in mice^[1].
CADD522 (10 mg/kg; i.p.; twice a week for 11 days) suppresses tumor metastasis and inhibits expression of Ki-67 in mice^[1].

Animal Model:	Female mice (6-week-old; MMTV-PyMT transgenic model)^[1].
Dosage:	1, 5 and 20 mg/kg
Administration:	Intraperitoneal injection; twice a week for 45 days.
Result:	Delayed the onset of the tumors, delayed tumor development and reduced tumor burden in transgenic MMTV-PyMT mice. Reduced the tumor weight in mice.

Animal Model:	Female NOD scid gamma (NSG) mice and nude mice (TNBC-PDX Br-001 model)^[1].
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; twice a week for 11 days.
Result:	Significant decreased tumor volume and markedly inhibited expression of Ki-67. Inhibited experimental metastasis of BC cells in vivo.(did not significantly decrease body weight or influence the general health of animals).

IC 50

RUNX2: 10 nM ()

Spectrum Detail

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Tianjin Kailiqi Biotechnology Co., Ltd.

Telephone 15076683720

Websitehttp://www.cw-bio.com

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Shanghai Rechem science Co., Ltd.

Telephone021-31433387 15618786686

Websitehttp://cn.rechemscience.com

Beijing Solarbio Science & Tecnology Co., Ltd.

Telephone17801761073 18101056239

Websitehttp://www.solarbio.com

MQ (shanghai) Pharmaceuticals Co., Ltd.

Telephone 13761635123

Websitehttp://www.linyuepharm.com/

Wuhan ChemNorm Biotech Co.,Ltd.

Telephone+86-27-8439 4403 18971486879

Websitehttp://www.chemnorm.com

Shanghai hongqu biomedical technology co. LTD

Telephone 88888888888

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList873228/0_EN.htm

Wuhan ChemNorm co., LTD.

Telephone 18971486879

Websitehttp://www.chemnorm.com

Abmole Bioscience Inc.

Telephone 19821158099

Websitehttp://www.abmole.cn/

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

Kaifeng Mingren Pharmaceutical Co.,LTD

Telephone0371-65741762

Websitehttps://www.kfmryy.com/

InvivoChem

Telephone 13549236410

Websitehttps://www.invivochem.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Shanghai Jieshikai Biotechnology Co. , Ltd.

Telephone021-57520305 13795461237

Websitehttps://www.jskchem.com

1of4

Related Products

Send Inquriy