Description
Indobufen is a platelet aggregation inhibitor related to the antiinflammatory agent
indoprofen. It has shown clinical efficacy in peripheral artery disease, in
prevention of deep vein thrombosis after myocardial infarction, and in blocking
excercise-induced increase in platelet aggregation in angina patients.
Originator
Erbamont (Italy)
Uses
Indobufen is a platelet aggregation inhibitor. Indobufen is the anticoagulant drug and platelet aggregation inhibitor, which has anti-inflammatory analgesic effect. Indobufen is used as an antithrombotic.
Definition
ChEBI: Indobufen is a member of isoindoles.
Clinical Use
A reversible but very potent inhibitor of platelet COX-1 activity,
was shown to have comparable clinical efficacy to that of aspirin in prevention of DVT after
myocardial infarction and in blocking exercise-induced increase in platelet aggregation. In the
secondary prevention of thromboembolic events, 100 or 200 mg of indobufen twice daily is as
effective as warfarin or aspirin in patients with or without atrial fibrillation. Currently,
indobufen is only available for routine clinical use in Europe.
