Uses
Monascin is an azaphilonoid pigment extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration.
Definition
ChEBI: An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl an
methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of car
inogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
Biochem/physiol Actions
Monascin is one of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mold rice). It is a potent inhibitor of carcinogenesis measured against chemical or UV initiated, phorbol-promoted mouse skin tumors.
References
[1] WEI-HSUAN HSU . Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice[J]. Food and Chemical Toxicology, 2014, 64: Pages 94-103. DOI:
10.1016/j.fct.2013.11.015[2] TOSHIHIRO AKIHISA. Anti-Tumor-Initiating Effects of Monascin, an Azaphilonoid Pigment from the Extract of Monascus pilosus Fermented Rice (Red-Mold Rice)[J]. Chemistry & Biodiversity, 2005, 2 10: 1305-1309. DOI:
10.1002/cbdv.200590101[3] YEU-CHING SHI Tzu M P Vivian Hsiu Chuan Liao. Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans[J]. Free Radical Biology and Medicine, 2012, 52 1: Pages 109-117. DOI:
10.1016/j.freeradbiomed.2011.09.034
