Description
Camphene is a colorless to white crystallinesolid with camphor-like odor. It may be shipped as a liquid.Freezing/Melting point=50℃. Molecular weight=136.24;Boiling point=159℃; Melting point=37℃; Flashpoint=42℃ (oc); 33℃ (cc). Hazard Identification (basedon NFPA-704 M Rating System): Health 2, Flammability 3,Reactivity 0. Insoluble in water.
Chemical Properties
Camphene is a colorless to white crystalline
solid, Camphor, or turpentine odor. It may be shipped as a
liquid. Freezing/Melting point 5 50C.
Chemical Properties
WHITE CRYSTALLINE LOW MELTING SOLID
Chemical Properties
Camphene has a terpene, camphoraceous taste.
Occurrence
Reported found in carrot, dill, fennel, marjoram, nutmeg, parsley, pepper, tarragon and thyme.
Uses
Camphene is used in the preparation of fragrances and as a food additive for flavoring.
Uses
Manufacture of synthetic camphor, camphor
substitute.
Preparation
From pinene by catalytic isomerization or from bornyl chloride by heating with alkali in the presence of abietenesulfonic acid.
Definition
ChEBI: A monoterpene with a bicyclic skeleton that is bicyclo[2.2.1]heptane substituted by geminal methyl groups at position 2 and a methylidene group at position 3. It is a widespread natural product found in many essential oils.
Aroma threshold values
Detection at 10%: camphoraceous, cooling, piney woody with terphy nuances. It has citrus and green
minty and green spicy notes.
Taste threshold values
Taste characteristics at 50–100 ppm: camphoraceous, cooling, minty, with citrus and green spicy nuances.
General Description
A colorless to white crystalline solid with an insipid camphor-like odor. Dust and crystals are irritants to the eyes, nose and throat. Emits flammable vapors when heated. Emits acrid smoke and irritating fumes at high temperature. Used for the manufacture of synthetic camphor.
Reactivity Profile
Camphene may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
Hazard
Toxic by ingestion.
Health Hazard
Inhalation causes irritation of nose and throat. Contact with eyes or skin causes irritation.
Flammability and Explosibility
Flammable
Pharmacology
Oral administration of camphene (260 mmols/kg) to rats increased bile flow by 50%
4 hr after administration (Mrsdorf, 1966). Development of atheromatosis of the aorta in rabbits
fed 1 g cholesterol/day for 3 months was considerably inhibited by simultaneous administration
of a mixture of terpenes including camphene, injected sc in a dose of 1 ml every other day for
6 wk and then given orally in doses of 2 ml/day (Benk, Macher, Szarvas & Tiboldi, 1961). The
effect of 1 g cholesterol/day for 8 wk in the diet of rabbits in increasing the number and volume
of mast cells in the aortic adventitia and increasing the total lipid content of the aortic wall was
slightly enhanced by the simultaneous addition of 11 g camphene/day (Lesznyak, Benko, Szabo
& Muller, 1972). This camphene treatment also decreased the lipid accumulation in the liver, but
had no effect on the cholesterol-induced atheromatosis of the aorta (Benko, Szabo, Muller & Lesznyak,
1972).
Anticancer Research
This was tested against melanoma cells in a syngeneic model, and there was promisingantitumor activity (Ma et al. 2016).
Safety Profile
Mutation data reported.
Combustible; yields flammable vapors when
heated and can react with oxidizing
materials. To fight fire, use water spray,
foam, fog, CO2. When heated to
decomposition it emits acrid smoke and
irritating fumes.
Potential Exposure
Camphene is used to manufacture synthetic camphor; for making moth-proofing and in the cosmetics, perfume, and food flavoring industries.
First aid
f this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at leastCamphene 54715 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
storage
Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. Prior to working with camphene you shouldbe trained on its proper handling and storage. Camphenemust be stored to avoid contact with strong oxidizers(such as chlorine, bromine, and fluorine) since violentreactions occur. Store in tightly closed containers in acool, well-ventilated area. Sources of ignition, such assmoking and open flames, are prohibited where Campheneis used, handled, or stored in a manner that could create apotential fire or explosion hazard. Use only nonsparkingtools and equipment, especially when opening and closingcontainers of camphene.
Shipping
UN1325 Flammable solids, organic, n.o.s.,
Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN2319
Terpene hydrocarbons, n.o.s., Hazard Class: 3; Labels: 3-
Flammable liquid
Incompatibilities
Forms explosive mixture with air.
Emulsions in xylene may violently decompose on contact
with iron or aluminum above 70C. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact
with reducing agents may cause exothermic reaction,
releasing flammable hydrogen gas
Toxics Screening Level
The ITSL for Camphene is 80 μg/m3, with annual averaging time.
Waste Disposal
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed.
