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2,2,2-TRIFLUOROETHYL VINYL ETHER

2,2,2-TRIFLUOROETHYL VINYL ETHER Structure
2,2,2-TRIFLUOROETHYL VINYL ETHER
  • CAS No.406-90-6
  • Chemical Name:2,2,2-TRIFLUOROETHYL VINYL ETHER
  • CBNumber:CB5761492
  • Molecular Formula:C4H5F3O
  • Formula Weight:126.08
  • MOL File:406-90-6.mol
2,2,2-TRIFLUOROETHYL VINYL ETHER Property
Safety
  • Hazard Codes  :F,Xi
  • Risk Statements  :11-41-10
  • Safety Statements  :16-36-39-26
  • RIDADR  :1993
  • RTECS  :KO4250000
  • Hazard Note  :Flammable
  • TSCA  :Yes
  • HazardClass  :3
  • PackingGroup  :II
  • Toxicity :mmo-sat 3 pph/2H MUREAV 58,183,78
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H225-H341
  • Precautionary statements P201-P210-P280-P303+P361+P353-P405-P501a

2,2,2-TRIFLUOROETHYL VINYL ETHER Chemical Properties,Usage,Production

  • Originator Fluoromar, Ohio Medical, US ,1961
  • Uses Ca channel blocker, coronary vasodilator
  • Manufacturing Process The following process description is taken from US Patent 2,830,007.
    270 grams 2,2,2-trifluoroethanol was added slowly to 15 grams of a cooled suspension of potassium metal in 250 ml of ethyl ether with stirring. When all the potassium metal had reacted, the resulting solution was fractionally distilled in order to remove the ethyl ether. The residue was placed in a bomb and the air was removed from the bomb by flushing with acetylene. The bomb was sealed and heated to 150°C. Acetylene was then introduced at 245 to 260 psi and the gas pressure was maintained for a period of 5 hours under mechanical agitation throughout the reaction. At the end of this time, heating was discontinued, the flow of acetylene was shut off and the bomb was allowed to cool to room temperature. The excess pressure in the bomb was reduced to atmospheric pressure by venting any gases through a dry ice cooled trap.
    The reaction mixture comprising 2,2,2-trifluoroethyl vinyl ether, 2.2.2trifluoroethanol and potassium 2,2,2-trifluoroethylate was fractionally distilled, whereupon crude 2,2,2-trifluoroethyl vinyl ether was obtained which boiled at 42° to 45°C at 760 mm. More 2,2,2-trifluoroethyl vinyl ether was obtained when the distillation residue was returned to the bomb and reacted with acetylene in the same manner as hereinabove described.
    The alkali metal hydroxides, instead of the alkali metals per se, can be employed to produce the alkali metal 2,2,2-trifluoroethanolate. However, this introduces water in the reaction mixture which requires removal prior to vinylation with acetylene. The crude products, on further distillation, yielded 2,2,2-trifluoroethyl vinyl ether having a boiling point of 43.1°C at 759 mm.
  • Therapeutic Function Inhalation anesthetic
  • General Description Volatile Liquid. Bp: 43°C. Density: 1.14 g cm-3 . Formerly used as an inhalation anesthetic.
  • Reactivity Profile 2,2,2-TRIFLUOROETHYL VINYL ETHER is non-flammable but combustible. Can form explosive mixtures with air. Reacts with strong oxidizing agents.
  • Safety Profile Poison by inhalation. Moderately toxic by intraperitoneal route. An experimental teratogen. Human systemic effects by inhalation: jaundice and liver function tests impaired. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F-. Used as an anesthetic. See also FLUORIDES and ETHERS.
2,2,2-TRIFLUOROETHYL VINYL ETHER Preparation Products And Raw materials
Raw materials
Preparation Products
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406-90-6, 2,2,2-TRIFLUOROETHYL VINYL ETHERRelated Search:
  • fluoroxene
  • fluorxene
  • fluroxene
  • trifluoroethylvinylether
  • 2,2,2-TRIFLUOROETHYL VINYL ETHER
  • 2,2,2-TRIFLUOROETHYL VINYL ETHER, 97%, STAB. WITH 0.1% TRIET
  • 2,2,2-Trifluoroethyl vinyl ether, 97%, stab.
  • Fluroxen
  • (2,2,2-Trifluoroethoxy)ethene, Fluoroxene
  • fluoromar
  • 2,2,2-Trifluoroethyl vinyl ether 97%
  • 2,2,2-Trifluoroethylvinylether97%
  • 2,2,2-trifluoroethoxyethylene
  • (2,2,2-Trifluoroethoxy)ethylene, Fluroxene
  • Flurossene
  • 2,2,2-Trifluoroethyl vinyl ether, stabilized
  • (2,2,2-trifluoroethoxy)-ethen
  • (2,2,2-trifluoroethoxy)ethene
  • ethene,(2,2,2-trifluoroethoxy)-
  • ether,2,2,2-trifluoroethylvinyl
  • floroxene
  • fluooxene
  • 406-90-6
  • H2CCHOCH2CF3
  • CARDIZEM