Chemical Properties
white to light purple or purple-brownish powder
Uses
2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.
Definition
ChEBI: A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.
General Description
2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).
Purification Methods
Crystallise it from MeOH. It has m 200-201o after sublimation in a vacuum. The picrate has m 132o after crystallisation from Et2O. [Gibson et al. J Chem Soc 4340 1955, Beilstein 21 III/IV 1057, 21/8 V 217.]
