2-(4-Aminophenyl)ethylamine

Chemical Properties

clear light yellow to brown-yellow viscous liquid

Uses

4-(2-Aminoethyl)aniline has been used in chemical modification of silk fibroin to tailor the overall hydrophilicity and structure of silk. It has been used as reagent in polycondensation reactions.

Application

2-(4-Aminophenyl)ethylamine (APEA) is an important amine compound for the study of reductive amination with 3-deoxy-d-mannuronic acid (Kdo) and for the synthesis of new heat-resistant biopolyureas by fermentation techniques^[1-2].

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5219, 1984 DOI: 10.1016/S0040-4039(01)81568-9

General Description

4-(2-Aminoethyl)aniline undergoes coupling with carbohydrates by reductive amination to yield modified carbohydrates.

References

[1] H D GRIMMECKE; H B. Studies on the reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo).[J]. Glycoconjugate Journal, 1998. DOI:10.1023/a:1006955508077.
[2] HAJIME MINAKAWA. Fermentative production of 2-(4-aminophenyl)ethylamine to synthesize a novel heat-resistant biopolyurea.[J]. Bioscience, Biotechnology, and Biochemistry, 2022. DOI:10.1093/bbb/zbac077.