Chemical Properties
colourless liquid
Uses
A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.
Definition
ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 27, p. 347, 1984
DOI: 10.1021/jm00369a019
General Description
Colorless to dark red liquid.
Air & Water Reactions
Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.
Reactivity Profile
Phenetidine reacts vigorously with powerful oxidizers.
Fire Hazard
Phenetidine is combustible.
Safety Profile
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
