Chemical Properties
yellow powder
Uses
9-Aminoacridine hydrochloride is a known mutagen and DNA modifier.
General Description
Bright yellow to yellow-green powder.
Air & Water Reactions
9-Aminoacridine hydrochloride hydrate is sensitive to prolonged exposure to air . Slightly soluble in water.
Reactivity Profile
Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Health Hazard
SYMPTOMS: Symptoms of exposure to 9-Aminoacridine hydrochloride hydrate include irritation of the gastrointestinal mucosa, nausea and vomiting.
Fire Hazard
Flash point data are not available for 9-Aminoacridine hydrochloride hydrate, but 9-Aminoacridine hydrochloride hydrate is probably combustible.
Purification Methods
Recrystallise it from boiling H2O (charcoal; 1g in 300 mL) to give pale yellow crystals with a neutral reaction. It is one of the most fluorescent substances known. At 1:1000 dilution in H2O it is pale yellow with only a faint fluorescence, but at 1:100,000 dilution it is colourless with an intense blue fluorescence. [Albert & Ritchie Org Synth Coll Vol III 53 1955; Falk & Thomas Pharm J 153 158 1944, Beilstein 22 H 463, 21 II 280, 21 III/IV 4174.] See previous entry for the free base.
