Uses
Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure.
Description
Aminoguanidine is equipotent to L-
NMMA and L-
NNA as an inhibitor of iNOS. The IC
50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.
Chemical Properties
white to off-white crystals
Uses
Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both
Escherichia coli and
Staphylococcus aureus.
Uses
a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin
General Description
Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Inhibits both constitutive and inducible nitric oxide synthetase.
