Description
Dichlormid is a herbicide ‘safener’ currently approved by the U.S. Environmental Protection Agency (USEPA) for use on corn pasture and stover to protect corn from injury with chloroacetanilide and thiocarbamate herbicides; and to protect rice and wheat from etofenprox, butachlor, alachlor, grass, Lasso, tri-allate, Ordram, Simagine, and other herbicides.
Chemical Properties
Dichlormid is a colorless to pale yellow viscous liquid that is easily soluble in water, highly volatile in water, and generally does not persist in soil.
Uses
Dichlormid is a chemical that in vitro has been shown as a potential herbicide for weed control.
Definition
ChEBI: Dichlormid is a tertiary carboxamide.
in vitro
Dichlormid was shown to increase glutathione-S-transferase activity in vitro, upregulated the expression of ZmGST27 and ZmMRP1, and increased the expression of ZmGT1
[1].
Toxicity evaluation
Dichlormid has an acute oral toxicity LD50 of 2000 mg/kg (rat), an inhalation LC50/4 h of 11 mg/L, and is non-irritating to the skin and eyes. It is moderately toxic to mammals, has a high bioaccumulation potential, and is relatively non-toxic to birds, fish, and aquatic invertebrates.
References
[1] SEN PANG. Co-induction of a glutathione-S-transferase, a glutathione transporter and an ABC transporter in maize by xenobiotics.[J]. ACS Applied Bio Materials, 2012: e40712. DOI:10.1371/journal.pone.0040712.
