Description
Polydatin is a stilbene glucoside and a precursor to
trans-resveratrol (Item No. 70675) that has been found in
V. vinifera and has diverse biological activities. It scavenges DPPH radicals and inhibits copper-induced lipid peroxidation (IC
50s = 198 and 19.1 μM, respectively). Polydatin inhibits the proliferation of, and induces cell cycle arrest at the S phase in, Caco-2 colon cancer cells. It decreases infarct size, cardiomyocyte fibrosis, and apoptosis in a mouse model of myocardial ischemia-reperfusion injury induced by left anterior descending (LAD) coronary artery occlusion when administered at a dose of 40 mg/kg per day.
Chemical Properties
Off-White Solid
Uses
A Stilbenoid glucoside and is a major Resveratrol derivative.
Definition
ChEBI: A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
References
[1] PIERRE WAFFO TEGUO. Isolation, Identification, and Antioxidant Activity of Three Stilbene Glucosides Newly Extracted from Vitis vinifera Cell Cultures[J]. Journal of Natural Products , 1998, 61 5: 655-657. DOI:
10.1021/np9704819[2] SALVATORE DE MARIA. Polydatin, a natural precursor of resveratrol, induces cell cycle arrest and differentiation of human colorectal Caco-2 cell.[J]. Journal of Translational Medicine, 2013: 264. DOI:
10.1186/1479-5876-11-264[3] MING D, SONGYAN L, YAWEN C, et al. trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin–angiotensin system (RAS) and Rho kinase (ROCK) activity[J]. Food & Function, 2017, 6: 2309-2321. DOI:
10.1039/c6fo01842d
