Description
Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.
Chemical Properties
White Crystalline Solid
Uses
inhibitor of glucosidases
Definition
ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.
General Description
Conduritol B epoxide(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Biochem/physiol Actions
Conduritol B epoxide(CBE)is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).
References
[1] SUBHASH C. DATTA Norman S R. Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection[J]. Biochemical and biophysical research communications, 1988, 152 1: Pages 155-160. DOI:
10.1016/s0006-291x(88)80693-4[2] N S RADIN R R V. Inhibitors of cerebroside metabolism.[J]. Methods in enzymology, 1981, 72: 673-684. DOI:
10.1016/s0076-6879(81)72057-3[3] M.CARLA STEPHENS . Distribution of conduritol B epoxide in the animal model for Gaucher’s disease (Gaucher mouse)[J]. Biochimica et biophysica acta. General subjects, 1981, 672 1: Pages 29-32. DOI:
10.1016/0304-4165(81)90276-2[4] DAVID S. NEWBURG. β-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986, 877 1: Pages 121-126. DOI:
10.1016/0005-2760(86)90126-8
