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Glibenclamide Structure

Glibenclamide

Chemical Properties

Melting point 173-175°C
Density  1.1805 (rough estimate)
refractive index  1.6100 (estimate)
storage temp.  2-8°C
solubility  ethanol: soluble2mg/mL
form  White solid
pka 5.3(at 25℃)
color  White
Water Solubility  Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
Merck  14,4478
BCS Class 2
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N
CAS DataBase Reference 10238-21-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII SX6K58TVWC
NCI Drug Dictionary Diabeta
ATC code A10BB01
NIST Chemistry Reference Glyburide(10238-21-8)
EPA Substance Registry System Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- (10238-21-8)

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H370
Precautionary statements P260-P264-P270-P308+P311-P405-P501
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  22-36/37/39-36-24/25
WGK Germany  2
RTECS  YS4725200
HS Code  29350090
Toxicity LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami)
NFPA 704:
1
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