Description
4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.
Chemical Properties
White Solid
Uses
4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.
Uses
A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes
Definition
ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.
References
[1] J O MINERS D J B. Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.[J]. Methods in enzymology, 1996, 272: 139-145. DOI:
10.1016/s0076-6879(96)72017-7[2] VAN NGUYEN Fawzy E Michael Espiritu. Development and validation of a sensitive and specific LC-MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity.[J]. Biomedical Chromatography, 2020, 34 3: e4789. DOI:
10.1002/bmc.4789
