Conduritol B epoxide

Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.

White Crystalline Solid

inhibitor of glucosidases

ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.

Conduritol B epoxide(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.

Conduritol B epoxide(CBE)is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).

Store at -20°C

[1] SUBHASH C. DATTA  Norman S R. Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection[J]. Biochemical and biophysical research communications, 1988, 152 1: Pages 155-160. DOI:10.1016/s0006-291x(88)80693-4
[2] N S RADIN  R R V. Inhibitors of cerebroside metabolism.[J]. Methods in enzymology, 1981, 72: 673-684. DOI:10.1016/s0076-6879(81)72057-3
[3] M.CARLA STEPHENS . Distribution of conduritol B epoxide in the animal model for Gaucher’s disease (Gaucher mouse)[J]. Biochimica et biophysica acta. General subjects, 1981, 672 1: Pages 29-32. DOI:10.1016/0304-4165(81)90276-2
[4] DAVID S. NEWBURG. β-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986, 877 1: Pages 121-126. DOI:10.1016/0005-2760(86)90126-8