Chemical Properties
Clear colorless to yellow liquid
Uses
2-Chloro-5-(chloromethyl)thiophene was used in the synthesis of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1
H-imidazol-1-yl)propane and 1-(5-chlorothiophen-2-yl)-2-(1
H-imidazol-1-yl)-3-phenylpropane.
Synthesis
Under nitrogen protection, 5-chloro-2-thiophene methanol (500 mg, 3.37 mmol) was dissolved in tetrahydrofuran (10 mL) and cooled to 0 °C. Subsequently, CN (482 mg, 4.05 mmol) was added dropwise. After the dropwise addition, the reaction mixture was warmed up to 50 °C for 3 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 480 mg of 2-chloro-5-chloromethylthiophene in yellow liquid form (yield: 85.5%), which could be used directly in the subsequent reaction without further purification.
References
[1] Patent: CN107188865, 2017, A. Location in patent: Paragraph 0113; 0116; 0117
