Broussonin A

Description

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A and nyasol suppress lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. 3. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. 4. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.

target

NOS | Akt | ERK | Estrogen receptor | IFN-γ | IL Receptor | NF-kB | IkB | IKK | Progestogen receptor