Description Hypoglycemic agents Pharmacological effects Pharmacokinetics Synthetic method Uses Side effects Contraindications Precautions Drug interactions References
ChemicalBook > CAS DataBase List > Gliclazide


Description Hypoglycemic agents Pharmacological effects Pharmacokinetics Synthetic method Uses Side effects Contraindications Precautions Drug interactions References
Gliclazide Structure
  • CAS No.21187-98-4
  • Chemical Name:Gliclazide
  • CBNumber:CB5113462
  • Molecular Formula:C15H21N3O3S
  • Formula Weight:323.41
  • MOL File:21187-98-4.mol
Gliclazide Property
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :21-36/38-46-62-63
  • Safety Statements  :25-26-36/37-53-24/25
  • RIDADR  :3077
  • WGK Germany  :2
  • RTECS  :YT4500000
  • HS Code  :29350090
  • Toxicity :LD50 orally in mice: >3 g/kg (Duhault)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Gliclazide Price More Price(9)
  • Brand: Sigma-Aldrich
  • Product number: PHR1288
  • Product name : Gliclazide
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 1g
  • Price: $72.8
  • Updated: 2021/03/22
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  • Brand: Sigma-Aldrich
  • Product number: G2167
  • Product name : Gliclazide
  • Purity: powder, ≥98%
  • Packaging: 5g
  • Price: $132
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: G0326000
  • Product name : Gliclazide
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: G0381
  • Product name : Gliclazide
  • Purity: >98.5%(HPLC)(T)
  • Packaging: 5g
  • Price: $58
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 25503
  • Product name : Gliclazide
  • Purity: ≥98%
  • Packaging: 1g
  • Price: $25
  • Updated: 2021/03/22
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Gliclazide Chemical Properties,Usage,Production

  • Description Gliclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.
  • Hypoglycemic agents Gliclazide, chemical name is 1-(hexahydrocyclopenta [c] pyrrole-2 (1H)-yl)-3-(4-methylphenyl) sulfonyl urea, is the second generation of sulfur ureide oral hypoglycemic agents, and it also has dual function of hypoglycemic and improving blood clotting. It not only can improve the metabolism of diabetic patients, but also can improve or delay the occurrence of diabetic vascular complications. Gliclazide was developed by the French SERVIER company, and listed in France as early as 1972. Its trade names are diamicron gliclazide, methanesulfonic bicyclic urea to g pancreas, methanesulfonic grid urea, glick that sa. It is mainly used for the treatment of the onset of diet and exercise alone control ineffective of adulthood, and no ketosis tendency of light, moderate the type II diabetes. It also can improve diabetic retinopathy and metabolic disorders, vascular function. It can be used with biguanide oral hypoglycemic drugs, and used with insulin to treat insulin-dependent diabetes mellitus, in which condition that insulin dosage can be reduced. 1980s, it began to be supplied into the Chinese market. Now there has been more than 130 countries worldwide that registered and sold.
  • Pharmacological effects 1. Hypoglycemic effect: gliclazide is the second-generation oral sulfonylurea hypoglycemic agents. Its role is more than ten times stronger than tolbutamide. Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target tissue to insulin.
    2. It can reduce platelet aggregation and adhesion, and prevent fibrin depositing in the microvasculature.
    3. It can lower cholesterol savings, and reduce plasma concentrations of arterial triphosphate glycerides and fatty acids. The role of the three not only can treat diabetes metabolic disorders, but also prevent and treat complications like the development and progression of diabetes-blood vessels, retinal, renal disease.
  • Pharmacokinetics The absorption of gliclazide is rapidly when it is taken orally. The plasma concentration peaks after two to six hours. Plasma protein binding rate is 94.2%. Τ1/2 is about 12 hours. Gliclazide is mainly used in the liver metabolism, and its metabolites has no hypoglycemic effect. 98% is excreted by kidney in less than 48 hours, and the content of unchanged drug in the urine is less than 5%.
  • Synthetic method Cyclopentane ortho anhydride as raw materials, ammoniates to obtain cyclopentane phthalimide. It reacts to obtain azabicyclo through catalytic reduction by catalysts like LiAlH4, KBH4/ZnCl2 or black platinum. And then azabicyclo reacts to give N-3-azabicyclo [3, 3, O] octane hydrochloride by nitrosation, zinc reduction. Finally it reacts with toluene sulfonylurea to obtain gliclazide through condensation.

    Figure 1 The synthetic route of gliclazide
  • Uses 1. For adults with type 2 diabetes, diabetes associated with obesity or vascular lesions.
    2. Hypoglycemic agents. It can be used for the treatment of non-insulin dependent diabetes mellitus.
    3. Hypoglycemic agents, non-insulin dependent diabetes mellitus.
    The above information is edited by the Chemicalbook of Ge Qian.
  • Side effects Occasional mild nausea, vomiting, abdominal pain, constipation, diarrhea, erythema, urticaria, thrombocytopenia, neutropenia, anemia. Most adverse reactions disappeared after withdrawal.
  • Contraindications 1. Forbidden for patients allergic to gliclazide or sulfonylureas, sulfa drugs.
    2. Forbidden for patients with type 1 diabetes.
    3. Forbidden for patients with diabetic pre-coma, diabetic ketoacidosis.
    4. Forbidden for patients with severe liver and kidney dysfunction.
    5. Forbidden for leukopenia patients.
    6. Forbidden for patients with stress situations like coma, severe burns, infection, trauma and major surgery.
    7. Forbidden for patients with pregnant and lactating women
  • Precautions 1. When patients with type 2 diabetes have infection, trauma, surgery, stress situations and ketoacidosis and hyperosmolar nonketotic diabetic coma, insulin therapy should be used instead.
    2. When the overdose of gliclazide, eating too little or strenuous exercise, you should take attention to prevent hypoglycemia.
    3. You must regularly check blood sugar, urine, and take eye examinations.
    4. When gliclazide is combined with anticoagulants, you should have regular blood clotting check.
  • Drug interactions When gliclazide is used with nonsteroidal anti-inflammatory drug (especially salicylates), sulfa antibiotic, double coumarin anticoagulants, monoamine oxidase inhibitors, β-blockers, tetracycline, chloramphenicol, dicyclohexyl B piperidine, clofibrate, ethanol and other drugs, its dosage should be reduced to avoid hypoglycemia reaction.
  • References
    Fava, D, et al. "Gliclazide improves anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes." Diabetic Medicine A Journal of the British Diabetic Association 19.9(2002):752.
    Kimoto, K, et al. "Gliclazide protects pancreatic beta-cells from damage by hydrogen peroxide. " Biochemical & Biophysical Research Communications 303.1(2003):112-119.
  • Chemical Properties White Cyrstalline Solid
  • Originator Diamicron,Servier,France,1972
  • Uses antidiabetic, adhesion inhibitor
  • Uses A sulfonylurea hypoglycemic agent. Used as an antidiabetic
  • Manufacturing Process To a suspension containing 4.86 parts of 4-methylbenzenesulfonyl urethane (MP 80° to 82°C) and 36 parts of anhydrous toluene there are rapidly added 2.5 parts of N-amino-3-azabicyclo(3.3.0)octane (BP/18 mm = 86°C). The reaction mixture is heated under reflux for 1 hour. The resulting clear solution crystallizes on cooling. The crystals are filtered, washed with 2 parts of toluene, then recrystallized from anhydrous ethanol. There are obtained 3.8 parts of the desired product, MP 180° to 182°C.
  • Therapeutic Function Oral hypoglycemic
  • General Description Chemically, gliclazide, 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea (Diamicron), isvery similar to tolbutamide, with the exception of the bicyclicheterocyclic ring found in gliclazide. The pyrrolidineincreases its lipophilicity over that of tolbutamide,which increases its half-life. Even so, the p-methyl is susceptibleto the same oxidative metabolic fate as observedfor tolbutamide, namely, it will be metabolized to a carboxylicacid.
Gliclazide Preparation Products And Raw materials
Raw materials
Preparation Products
  • Supplier:
    Sinoway Industrial co., ltd.
  • Tel:13806035118
  • Fax:0592-5854960
  • Country:CHINA
  • ProdList:311
  • Advantage:58
  • Supplier:
    Henan Tianfu Chemical Co.,Ltd.
  • Tel:0371-55170693
  • Fax:0371-55170693
  • Country:CHINA
  • ProdList:22607
  • Advantage:55
  • Supplier:
    Hangzhou FandaChem Co.,Ltd.
  • Tel:008615858145714
  • Fax:+86-571-56059825
  • Country:CHINA
  • ProdList:8910
  • Advantage:55
  • Supplier:
    Guangzhou PI PI Biotech Inc
  • Tel:+8618371201331
  • Fax:020-81716319
  • Country:China
  • ProdList:3245
  • Advantage:55
  • Supplier:
    career henan chemical co
  • Tel:+86-371-86658258
  • Fax:
  • Country:CHINA
  • ProdList:29954
  • Advantage:58
  • Supplier:
    Xiamen AmoyChem Co., Ltd
  • Tel:+86 592-605 1114
  • Fax:
  • Country:CHINA
  • ProdList:6369
  • Advantage:58
21187-98-4, GliclazideRelated Search:
  • Gliclazide, BP
  • )-4-methyl-
  • 1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea
  • 1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)-ure
  • 1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)urea
  • benzenesulfonamide,n-(((hexahydrocyclopenta(c)pyrrol-2(1h)-yl)amino)carbonyl
  • n-(4-methylbenzenesulfonyl)-n’-(3-azabicyclo(3.3.0)oct-3-yl)urea
  • Tetrabenzyl Voglibose HCl
  • 1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea
  • 3-[(3aR,6aS)-octahydrocyclopenta[c]pyrrol-2-yl]-1-[(4-Methylbenzene)sulfonyl]urea
  • Gliclazide analogue: N-[[(Hexahydrocyclopenta [c]pyrrol-2(1H)-yl)aMino]carbonyl]-2-Methyl benzenesulfonaMide
  • Tetrabenzyl Cycloketone ("TBC")
  • Methyl N-Methyl-p-tolylsulphoncarbaMate
  • etrabenzyl Voglibose HCl
  • TBC Tetrabenzyl Cycloketone
  • TBG Voglibose TBG Impurity
  • TBV HCl Tetrabenzyl Voglibose HCl
  • Gliclazide Impurity Ⅰ
  • Gliclazide, >=99%
  • s852
  • se1702
  • 1-[Hexahydrocylopenta [c] pyrrol-2[1H]-yl]-3-[p-tolylsulfonyl] urea
  • Cyclopenta[c]pyrrole, benzenesulfonamide deriv.
  • Diabezidum
  • Diabrezide
  • Diaprel
  • Glinormax
  • Glyzide
  • Urea, 1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)- (8CI)
  • GLICLAZIDE B.P. 2000
  • Gliclazide CP2000 BP98
  • Glibenclamide CP2000,BP93
  • Gliclazide BP98
  • 3-(7-azabicyclo[3.3.0]oct-7-yl)-1-(4-methylphenyl)sulfonyl-urea
  • 1-(3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
  • Gliclazide, 99%, whole-cell beta-cell ATP-sensitive potassium currents blocker
  • Methyl N-methyl-p-tolysulphoncarbomate
  • 1-(3-Azabicyclo[3.3.0]octan-3-yl)-3-(4-methylphenylsulfonyl)urea
  • N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methylbenzenesulfonamide
  • Gliclazide,1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea
  • 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea
  • AKOS NCG1-0056
  • SALOR-INT L255629-1EA
  • S-1702
  • Gliclazide&gt
  • Gliclazide CRS
  • GliclazideSolution,2000mg/L,4x1ml
  • Gliclazide fandachem
  • Gliclazide USP/EP/BP
  • Gliclazide (1.0 mg/mL in Methanol)