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1-Hydroxyethylidene-1,1-diphosphonic acid

1-Hydroxyethylidene-1,1-diphosphonic acid  Structure
1-Hydroxyethylidene-1,1-diphosphonic acid
  • CAS No.2809-21-4
  • Chemical Name:1-Hydroxyethylidene-1,1-diphosphonic acid
  • CBNumber:CB4719658
  • Molecular Formula:C2H8O7P2
  • Formula Weight:206.03
  • MOL File:2809-21-4.mol
1-Hydroxyethylidene-1,1-diphosphonic acid Property
  • Melting point: :198~199℃
  • Boiling point: :578.8±60.0 °C(Predicted)
  • Density  :1.45 (60% aq.)
  • storage temp.  :Sealed in dry,Room Temperature
  • form  :Powder
  • pka :1.35, 2.87, 7.03, 11.3(at 25℃)
  • color  :white
  • PH :pH (1.7→100, 25℃) : 1.3~1.8
  • Water Solubility  :Soluble in water.
  • Merck  :14,3863
  • BRN  :1789291
  • Stability: :Stable. Incompatible with strong oxidizing agents.
  • InChIKey :DBVJJBKOTRCVKF-UHFFFAOYSA-N
  • CAS DataBase Reference :2809-21-4(CAS DataBase Reference)
  • Substances Added to Food (formerly EAFUS) :1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID
  • FDA 21 CFR :173.315
  • EWG's Food Scores :1-2
  • FDA UNII :M2F465ROXU
  • ATC code :M05BA01
  • EPA Substance Registry System :Etidronic acid (2809-21-4)
Safety
  • Hazard Codes  :Xi,Xn
  • Risk Statements  :37/38-41-22
  • Safety Statements  :26-39
  • RIDADR  :UN 3265
  • WGK Germany  :2
  • RTECS  :SZ8562100
  • F  :10
  • TSCA  :Yes
  • HazardClass  :8
  • PackingGroup  :II
  • HS Code  :29319090
  • Hazardous Substances Data :2809-21-4(Hazardous Substances Data)
  • Toxicity :LD50 oral in mouse: 1800mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H314-H303-H290-H318
  • Precautionary statements P260h-P301+P330+P331-P303+P361+P353-P501a-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501-P280-P305+P351+P338
1-Hydroxyethylidene-1,1-diphosphonic acid Price More Price(24)
  • Brand: Sigma-Aldrich
  • Product number: H6773
  • Product name : Etidronic acid
  • Purity: 60% aqueous solution
  • Packaging: 100g
  • Price: $51.6
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: H6773
  • Product name : Etidronic acid
  • Purity: 60% aqueous solution
  • Packaging: 500g
  • Price: $174
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: H0587
  • Product name : 1-Hydroxyethane-1,1-diphosphonic Acid (ca. 60% in Water, ca. 4.2mol/L)
  • Purity: 
  • Packaging: 25g
  • Price: $26
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: H0587
  • Product name : 1-Hydroxyethane-1,1-diphosphonic Acid (ca. 60% in Water, ca. 4.2mol/L)
  • Purity: 
  • Packaging: 500g
  • Price: $102
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: 043502
  • Product name : 1-Hydroxyethylidenebis(phosphonic acid), 96%
  • Purity: 
  • Packaging: 10g
  • Price: $109
  • Updated: 2021/12/16
  • Buy: Buy

1-Hydroxyethylidene-1,1-diphosphonic acid Chemical Properties,Usage,Production

  • Chemical Properties light beige powder
  • Originator Etidron,Gentili,Italy,1977
  • Uses 1-Hydroxyethylidenebis(phosphonic acid) acts as human protein tyrosine phosphatase inhibitor. It is also useful for photographic applications. It finds application to strengthen bone, osteoporosis treatment and to treat Paget's disease of bone. In addition, it is used in corrosion inhibition in circulating cool water systems, oil fields and low-pressure boilers with electric power, the chemical industry, metallurgy and fertilizers. It is also utilized for formulating reverse osmosis and thermal desalination anti-scaling agents. Furthermore, it is used in detergents, water treatment, cosmetics and pharmaceuticals.
  • Uses Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 μM.
  • Definition ChEBI: A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
  • Manufacturing Process Phosphorous acid was premixed with acetic acid to form a 50 wt % solution of phosphorous acid dissolved in acetic acid. The acids were mixed on a molar basis of 1.36:1, acetic acid to phosphorous acid, and this corresponded on a mol percentage basis to 57.6% acetic acid and 42.4% phosphorous acid. Acetic anhydride was continuously metered into a stream of the phosphorous acid-acetic acid mixture to form the reaction solution. The acetic anhydride was metered into the acid mixture at a mol ratio of 1.33 mols of acetic anhydride per mol of phosphorous acid. The metering rates were 18.5 lb/hr of the phosphorous acid/acetic acid premixed solution and 15.1 lb/hr acetic anhydride. The reaction solution was continuously passed through a heat exchanger where it was heated to 190°F then it was continuously fed into a two stage back-mix reaction zone where due to the heat of reaction the temperature rose to 275°F. The average residence in the reaction zone was 27 min. The reaction zone consisted of two back-mix reactors each having a capacity of 7.5 pounds of the reaction solution. A stream of reaction solution was continuously with drawn from the second reactor and continuously mixed with a stream of water which was being metered at a rate of 2 lb/hr. This amount of water corresponded to 18% excess over the theoretical amount necessary to hydrolyze all of the acetyl-containing compounds in the reaction solution to free acids. The hydrolyzed solution was continuously passed through a heat exchanger and cooled to room temperature after which the solution was continuously passed to a crystallizer where, with agitation, the ethane-1-hydroxy-1,1-diphosphonic acid crystallized. The slurry was then filtered and the crystals were recovered and dried. Analysis of the product showed a conversion rate of phosphorous acid to ethane-1-hydroxy-1,1- diphosphonic acid of 86%. Sodium hydroxide may be used to give the disodium salt.
  • brand name Didronel (Millot Laboratories, France); Didronel (Procter & Gamble).
  • Therapeutic Function Bone calcium regulator
1-Hydroxyethylidene-1,1-diphosphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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2809-21-4, 1-Hydroxyethylidene-1,1-diphosphonic acid Related Search:
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  • 1-Hydroxyethan-1,1-diphosphonsure
  • 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID HEDP
  • 1-Hydroxyethylidene-1,1-bis-(phosphonic acid)
  • 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID, 98% HEDP
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  • dequest2015
  • dequestz010
  • ehdp
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  • ferrofos510
  • 1000sl
  • 1-hydroxy-1,1-diphosphonoethane
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  • 1-hydroxyethanediphosphonicacid
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  • hydroxyethane-1,1-diphosphonicacid
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  • turpinalsl
  • 1-HYDROXYETHYLIDENE-1
  • 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID
  • 1-HYDROXYETHANE-1,1-BIS(PHOSPHONIC ACID)
  • 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
  • 1-HYDROXYETHYLIDENEDIPHOSPHONIC ACID
  • (1-HYDROXY-1-PHOSPHONO-ETHYL)-PHOSPHONIC ACID
  • ETIDRONIC ACID
  • HEDP
  • HEDPA
  • ETHANE-1-HYDROXY-1,1-DIPHOSPHONIC ACID
  • DEQUEST 2010
  • Etidronic Acid Monohydrate (1 g)
  • 1-diphosphonic acid
  • 1-Hydroxyethylidene-1,1-Diphosphonic Acid/HEDP Powder
  • (1-Hydroxyethane-1,1-diyl)diphosphonic acid
  • 1-Hydroxyethylidene-1,1-diphosphonic Acid Etidronic Acid
  • Etidronate (Didronel)
  • Etidronic acid,60% in water
  • 1-Hydroxyethane-1,1-diphosphonic acid, 60 wt.% solution in H2O
  • Etidronic acid Monohydrate (HEDP)