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A23187

A23187 Structure
A23187
  • CAS No.52665-69-7
  • Chemical Name:A23187
  • CBNumber:CB4315720
  • Molecular Formula:C29H37N3O6
  • Formula Weight:523.62
  • MOL File:52665-69-7.mol
A23187 Property
  • Melting point: :187-190 °C
  • alpha  :D25 -56° (c = 1 in chloroform)
  • Boiling point: :710.3±55.0 °C(Predicted)
  • Density  :1.28±0.1 g/cm3(Predicted)
  • storage temp.  :2-8°C
  • solubility  :Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
  • pka :pKa1 6.9 in 90% DMSO
  • form  :Solid
  • color  :white to light yellow
  • Merck  :13,1639
  • BRN  :1096801
  • FDA UNII :37H9VM9WZL
Safety
  • Hazard Codes  :Xi,Xn
  • Risk Statements  :36/37/38-20/21/22
  • Safety Statements  :26-36
  • WGK Germany  :3
  • RTECS  :DM4676000
  • F  :8
  • HS Code  :29349990
  • Toxicity :LD50 i.p. in mice: 10 mg/kg (Gale)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
A23187 Price More Price(17)
  • Brand: Sigma-Aldrich
  • Product number: 100105
  • Product name : A23187, Free Acid,
  • Purity: 
  • Packaging: 1mg
  • Price: $42.36
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 21186
  • Product name : Calcium ionophore III
  • Purity: Selectophore?, function tested
  • Packaging: 5 mg
  • Price: $109
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 100105
  • Product name : A23187, Free Acid,
  • Purity: 
  • Packaging: 5mg
  • Price: $109.15
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 21186
  • Product name : Calcium ionophore III
  • Purity: Selectophore?, function tested
  • Packaging: 25 mg
  • Price: $753
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63020
  • Product name : Antibiotic A23187, 98%
  • Purity: 
  • Packaging: 10mg
  • Price: $216
  • Updated: 2021/03/22
  • Buy: Buy

A23187 Chemical Properties,Usage,Production

  • Chemical Properties white to off-white solid
  • Uses Calcimycin is a potent calcium ionophore isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium-regulated cellular events.
  • Biological Activity Calcium ionophore that induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo .
  • Purification Methods It recrystallises from Me2CO as colourless needles. Protect it from light and moisture, store in a refrigerator. It is soluble in Me2SO or EtOH and can be stored for 3 months without loss of activity. The Mg and Ca salts are soluble in organic solvents and cross biological membranes. It has a pKa of 6.9 in 90% Me2SO. The Ca complex crystallises from 50% EtOH as colourless prisms. It is highly TOXIC. [Pressman Ann Rev Biochem 45 501 1976, Chaney et al. J Am Chem Soc 96 1932 1974, Chaney et al. J Antibiotics 29 124 1976, Suzuki et al. Anal Biochem 61 382 1989, Simon & Carafoli Methods Enzymol 56 439 1977.]
A23187 Preparation Products And Raw materials
Raw materials
Preparation Products
A23187 Suppliers
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52665-69-7, A23187Related Search:
  • A23187 (CalciMycin)
  • CALCIUM IONOPHORE III
  • CALCIUM IONOPHORE A23187
  • CALCIMYCIN
  • CALCIMYCIN A23187
  • IONOPHORE A-23187
  • 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • Bis[5-methylamino-2-[[(6S)-3β,9α,11β-trimethyl-8α-[(S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2β-yl]methyl]-4-benzoxazolecarboxylic acid]calcium salt
  • 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • 5-Methylamino-2-[[(2R,3R,6S)-3,9α,11β-trimethyl-8α-[(S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • Calcium ionophore A23187, 98%, from Streptomyces chartreusis
  • A 23187, CaliMycin
  • CalciuM Ionophore A23187, froM StreptoMyces chartreusis
  • Calcimycin [Calcium Ionophore A23187]
  • 4-Benzoxazolecarboxylicacid,5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-
  • CALIMYCIN;ANTIBIOTIC A 23187
  • A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem
  • Calcimycin hydrate
  • CALCIMYCIN HYDRATE
  • 4-BENZOXAZOLECARBOXYLIC ACID, 5-(METHYLAMINO)-2-((3,9,11-TRIMETHYL-8-(1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)ETHYL)-1,7-DIOXASPIRO(5.5)UNDEC-2-YL)METHYL)-(6S-(6ALPHA(2S*,3S*),8BETA(R),9BETA,11ALPHA))-
  • 5-(METHYLAMINO)-2-[[[2R,3R,6S,8S,9R,11R]-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID
  • A23187
  • ANTIBIOTIC A23187
  • 2-oxo-2-(1h-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl),(6s-(6-a
  • 3s*),8-beta(r*),9-beta,11-alpha))-lpha(2s
  • 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-4-benzoxazolecarboxylicaci
  • Calimycin
  • CALCIMYCIN A23187 FREE ACID
  • CALCIUM IONOPHORE (CALCIMYCIN) FREE ACID III
  • 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-, A23187 (free acid), Calcimycin, Calcium Ionophore A23187
  • Antibiotic A 23187, Calcium Ionophore A23187, Calimycin
  • Antibiotic A 23187, Calimycin
  • A23187, 98%, MIXED CALCIUM-MAGNESIUM SALT
  • A23187, 98%, FREE ACID
  • 52665-69-7
  • C29H36N3O6xCaxMg
  • C29H37N3O6
  • BioChemical
  • Antibiotics
  • Antibiotics A-F
  • Antibiotics A to Z
  • Signalling
  • antibiotic
  • Calcium channel