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A23187

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A23187 Basic information
  • Product Name:A23187
  • CAS:52665-69-7
  • MF:C29H37N3O6
  • MW:523.62
  • EINECS:258-084-1
  • Mol File:52665-69-7.mol
A23187 Chemical Properties
  • Melting point:187-190 °C
  • alpha D25 -56° (c = 1 in chloroform)
  • Boiling point:710.3±55.0 °C(Predicted)
  • Density 1.28±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
  • form Solid
  • pkapKa1 6.9 in 90% DMSO
  • color white to light yellow
  • Merck 13,1639
  • BRN 1096801
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-20/21/22
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS DM4676000
  • 8
  • HS Code 29349990
  • ToxicityLD50 i.p. in mice: 10 mg/kg (Gale)
MSDS
A23187 Usage And Synthesis
  • Chemical Propertieswhite to off-white solid
  • UsesCalcimycin is a potent calcium ionophore isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium-regulated cellular events.
  • Biological ActivityCalcium ionophore that induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo .
  • Purification MethodsIt recrystallises from Me2CO as colourless needles. Protect it from light and moisture, store in a refrigerator. It is soluble in Me2SO or EtOH and can be stored for 3 months without loss of activity. The Mg and Ca salts are soluble in organic solvents and cross biological membranes. It has a pKa of 6.9 in 90% Me2SO. The Ca complex crystallises from 50% EtOH as colourless prisms. It is highly TOXIC. [Pressman Ann Rev Biochem 45 501 1976, Chaney et al. J Am Chem Soc 96 1932 1974, Chaney et al. J Antibiotics 29 124 1976, Suzuki et al. Anal Biochem 61 382 1989, Simon & Carafoli Methods Enzymol 56 439 1977.]
A23187(52665-69-7)Related Product Information
A23187SupplierMore
  • Company Name:J & K SCIENTIFIC LTD.
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  • Company Name:Ascent Scientific
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