2-Amino-3-picoline

Chemical Properties

2-Amino-3-picoline is CLEAR YELLOW LIQUID AFTER MELTING

Uses

2-Amino-3-picoline is used in the synthesis of ketones from aldehydes.

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 4453, 1973 DOI: 10.1021/ja00794a070

Hazard

Toxic by ingestion.

Purification Methods

Recrystallise the picoline three times from *benzene, most of the residual *benzene being removed from the crystals by standing over paraffin wax chips in an evacuated desiccator. The amine is also transferred to a separating funnel under N2, and left in contact with NaOH pellets for 3hours with occasional shaking. It is then placed in a vacuum distilling flask where it is refluxed gently in a stream of dry N2 before fractionally distilling it. [Mod et al. J Phys Chem 60 1651 1956, Beilstein 22/9 V 212].