Description
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as
S. pneumoniae,
M. hominis, and anaerobic bacteria, including
B. fragilis.
Uses
Antibacterial (microbial DNA topoisomerase
inhibitor).
Uses
Temafloxacin is an antimicrobial quinolone drug.
Definition
ChEBI: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively. It is a quinolone, an amino acid, a monocarboxylic acid, an organofluorine compound, a secondary amino compound, a tertiary amino compound, a N-arylpiperazine and a quinolone antibiotic.
brand name
Omniflox (Abbott);8Omniflox 8Teflox 8Temac.
World Health Organization (WHO)
Temafloxacin, a quinolone antimicrobial, was introduced in 1991.
Shortly afterwards, its use became associated with severe adverse effects,
including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and
anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.
