Synthesis
100 g of thiophenic acid (780 mmol), 28 g of Cu2O (196 mmol), and 300 mL of toluene were added to a 500 mL three-necked round-bottom flask. The flask was fitted with a Dean-Stark condenser. The mixture was then refluxed for 3 days to remove water via azeotropic extraction. The yellowish-brown suspension was then cooled to ~60°C, and the product was collected in a glass sintered funnel (D-frit). The filter cake was washed with 300 mL of methanol under a nitrogen stream, followed by washing with Et2O until the filtrate was colorless, and then washed with 75 mL of hexane.
The product was dried under a nitrogen stream, then transferred to a flask and dried under vacuum to obtain COPPER(I) THIOPHENE-2-CARBOXYLATE (I) (70 g, 94%) as a light brown powder.
Chemical Properties
COPPER(I) THIOPHENE-2-CARBOXYLATE is Solid
Uses
Mediator in intermolecular cross-coupling reactions, asymmetric 1,4-additions, and allylation reactions.
Uses
Reactant or reagent involved in:
Studies of xenobiotic response to herbicide safener derivatives; Synthesis of functionalized BODIPY dye analogs; Orthogonal cross-coupling reactions; Preparation of parent borondipyrromethene system; Copper mediated cross-coupling
Uses
COPPER(I) THIOPHENE-2-CARBOXYLATE is used for studies of xenobiotic response safener derivatives, synthesis of functionalized BODIPY dye analogs, orthogonal cross-coupling reactions, preparation of parent borondipyrromethene system and Copper mediated cross-coupling.
reaction suitability
core: copper
reaction type: C-C Bond Formation
reagent type: catalyst
