Synthesis
p-Tert-butyl acetophenone was prepared as follows: in a 2 ml reaction vial 2-(4-(tert-butyl)phenyl)propan-2-ol (59.4 mg, 0.3 mmol), AgNO3 (1.6 mg, 3 mol%), Bi(OTf)3 (6 mg, 3 mol%) and K2S2O8 (245.8 mg. 3eq), and finally 2 wt% aqueous DAPGS-750-M (0.6 ml, 0.5 M) was added, followed by capping the reaction vial and stirring. After the stirring of the reaction solution, the reaction was extracted three times using ethyl acetate, and the organic phases of several extractions were combined into a 50 mL aubergine flask and processed for about 5 min using a Heidolph rotary evaporator with a rotational speed of 120 rpm, a temperature of 38 C, and a vacuum of 0.1 MPa, followed by column chromatography using a 200-mesh column chromatography silica gel with a unfolding agent of petroleum ether: ethyl acetate = 20: 1 Around, the target compound p-tert-butyl acetophenone was isolated. (42.8 mg, 81% yield, 98% purity by HPLC analysis, from the NMR profile, signal, noise, etc. can also reflect the product purity is very high).
