Description
Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.
Clinical application
Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.
Hazards
1,1,1,3,3,3-Hexafluoro-2-propanol derives from a propan-2-ol. It is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.
Preparation
1,1,1,3,3,3-Hexafluoro-2-propanol is prepared from hexafluoropropylene through hexafluoroacetone, which is then hydrogenated.
(CF3)2CO + H2 → (CF3)2CHOH
Description
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is aclear, colorless, oily, combustible liquid. Odor is describedasaromatic. Molecular weight = 1 68.04; Specific grav-ity = 1.596 .at 20℃; Freezing/Melting point= -4℃;Boiling point = 59℃at 760 mmHg; V apor pressure:556 mmHg at 51℃; 1468 mmHg at 75℃; Flash point: .>93℃. Hazard Identification (based on NFPA-704 MRating System): Health 3; Flammability 0; Reactivity 0.W ater soluble; solubility=≥100 mg/mL at 20℃.
Chemical Properties
Colorless liquid
Chemical Properties
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a
clear, colorless, oily, combustible liquid. Odor is described
as aromatic.
Uses
Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.
Uses
Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.
Uses
It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.
Uses
1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.
Definition
ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.
General Description
1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.
Air & Water Reactions
Water soluble.
Reactivity Profile
1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.
Fire Hazard
1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.
Potential Exposure
A specialty solvent for some poly mers; a lavatory reagent.
First aid
Eyes: Check the victim for contact lenses andremove. Flush victim's eyes with water or normal salinesolution for 20- 30 min, occasionally lifting lower andupper eyelids. Remove contaminated clothing and shoes.Get medical attention immediately. Do not put any oint-ments，oils， or medication in the victim's eyes withoutspecific instructions from a physician. Immediately trans-port the victim after flushing eyes to a hospital even ifno symptoms (such as redness or irritation) develop.Skin: Immediately flood affected skin with water andwash for at least 15 min. Remove and isolate all contami-nated clothing. Gently wash all affected skin areas thor-oughly with soap and water. If symptoms such as rednessor irritation develop， immediately calla physician.Transportthevictim toa hospital fortreatment.Inhalation: Remove victim to fresh air. If not breathing,give artificial respiration. If breathing is difficult, giveoxygen. Get medical attention immediately. Ingestion: Donot induce vomiting. If the victim is conscious and notconvulsing，give largeamountof water to dilute thechemical. Never give anything by mouth to an uncon-scious person. If symptoms (such as wheezing, coughing,shortness of breath, or burning in the mouth, throat, orchest) develop, call a physician. In all cases get medicalattention immediately. If the victim is convulsing orunconscious, do not give anything by mouth, ensure that .the victim's airway is open and lay the victim on his/herside with the head lower than the body.
storage
Color Code- White stripe (store separately):Contact Hazard; not compatible with materials in solidwhite category. Storage precautions: you should store thischemical in a refrigerator and keep it away from ox idizingmaterials. Store away from sources of ignition. Protectiveclothing (minimum protective clothing): if Tyvek-typedisposable protective clothing is not worn during handlingof this chemical, wear disposable Tyvek-type sleeves tapedto your gloves.
Shipping
UN1760 Corrosive liquids, n.o.s., Hazard class: 8;
Labels: 8-Corrosive material.
Purification Methods
Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.
Incompatibilities
HFIP is incompatible with acids, acid
chlorides, and oxidizing agents.
Waste Disposal
May be incinerated. In accor dance with 40CFR165, follow recommendations for the
disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office. Consult
with environmental regulatory agencies for guidance on
acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA
regulations governing storage, transportation, treatment,
and waste disposal.
